Genetics of schizophrenia spectrum disorders: looking back and peering ahead.

نویسندگان

  • Hon Cheong So
  • Eric Y H Chen
  • Pak C Sham
چکیده

The genetics of schizophrenia spectrum disorders have come a long way since the early demonstration of a substantial genetic component by family, twin and adoption studies. After over a decade of intensive molecular genetic studies, initially by linkage scans and candidate gene association studies, and more recently genome-wide association studies, a picture is now emerging that susceptibility to schizophrenia spectrum disorders is determined by many genetic variants of different types, ranging from single nucleotide polymorphisms to copy number variants, including rare and de novo variants, of pleiotropic effects on multiple diagnoses and traits. Further large-scale genome-wide association studies, and the forthcoming availability of affordable whole-genome sequencing technology, will further characterise the genetic variants involved, which in turn will be translated to improved clinical practice.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effectiveness of Family Psychological Training on Prevention of Recurrence of Symptoms in Patients with Schizophrenia Spectrum Disorders

Introduction: Schizophrenia spectrum disorders are one of the most common psychiatric disorders, meaning an abnormal mental state that is often described as "loss of contact with reality." Recurrence of symptoms and frequent hospitalizations are characteristics of patients with these disorders. The aim of this study was to determine the effectiveness of family psychoeducation education on the p...

متن کامل

The Effect of Community Re-entry Program on Therapeutic Compliance, Relapse and Rehospitalization of Patients with Schizophrenia Spectrum Disorders

Introduction: Conventional psychiatric treatments have weaknesses in the treatment of schizophrenia spectrum disorders and have little effect on skill-training and community-based areas. Therefore, the present study aimed to investigate the role of the Community Re-entry Program as a community-based complementary therapy in increasing therapeutic compliance and reduction of relapse and rehospit...

متن کامل

Association study of single nucleotide polymorphism rs165599 of COMT gene, with schizophrenia and bipolar mood disorder in the south-west of Iran

Linkage studies and epidemiological findings indicate that some possible genes in schizophrenia (SCZ) and bipolar mood disorder (BPD) are common. Numerous evidences for linkage of two diseases on chromosome 22 have been found. These findings suggest that one or more genes in the 22q11.21 region may be involved in the development of both disorders. In the present case-control study, association ...

متن کامل

Looking back, peering forward: what has been learned from the food-price spike of 2007–2008? - ODI Briefing 81 - Briefing papers;;Research reports and studies

متن کامل

The Effectiveness of Community Re-entry Program (CRP) in Increasing Preparedness for Discharge and Post-discharge Coping in Patients with Schizophrenia Spectrum Disorders

Introduction and Aim: Conventional psychiatric therapies have shortcomings in the treatment of schizophrenia spectrum disorders and have little effect on skills and community-based areas. Therefore, the present study aimed to investigate the role of community return program (CRP) as a community-based complementary therapy method in increasing readiness for discharge and post-discharge adjustmen...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Annals of the Academy of Medicine, Singapore

دوره 38 5  شماره 

صفحات  -

تاریخ انتشار 2009